Publication

Acute traumatic coagulopathy: the lethal triad of trauma

Howells, Mark
; 
Jones, Bridie
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Keyword
Emergency Medical Services
 Tramua
 Hypothermia
 Acidosis
 Haemorrhage
Journal Title
Journal of Paramedic Practice
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Publications - Welsh Ambulance Services University NHS Trust
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URI
http://hdl.handle.net/20.500.12417/1455
DOI
https://doi.org/10.12968/jpar.2018.10.12.510
Abstract
Trauma is the leading cause of death for people in the UK and North America, especially for those aged 15–24 years. However, if early management regimes of permissive hypotension, high-flow oxygen and administration of tranexamic acid are applied, mortality risk can be reduced significantly. Acute traumatic coagulopathy (ATC) is an internal process that is initiated by significant or massive trauma because of hypoperfusion resulting in hypovolaemic shock, activation of protein C, platelet dysfunction and disruption to the endothelial glycocalyx. ATC can be exacerbated by hypothermia, acidosis and dilution coagulopathy—the ‘lethal triad’ of trauma. This article discusses the pathophysiology of ATC and treatment strategies via the management of the lethal triad. Abstract published with permission
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