Lyon, RichardEgan, GerryGowens, PaulAndrews, PeterClegg, Gareth2021-11-252021-11-252010-08Lyon, R.M. et al, 2010. Issues around conducting prehospital research on out-of-hospital cardiac arrest: lessons from the TOPCAT study. Emergency Medicine Journal, 27 (8), 637-638.1472-02051472-021310.1136/emj.2009.087395http://hdl.handle.net/20.500.12417/1211Outcome from OHCA is primarily determined by prehospital events and meaningful clinical OHCA research must include data recorded in this setting. There is little evidence on which to base the practice of prehospital resuscitation and research in this area presents huge challenges but is required if survival from OHCA is to improve. This short report aims to provide a practical guide to performing prehospital research on OHCA, based on lessons learned from the Temperature Post Cardiac Arrest (TOPCAT) research; an observational study into OHCA. https://emj.bmj.com/content/27/8/637 This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. http://creativecommons.org/licenses/by-nc/4.0/ DOI http://dx.doi.org/10.1136/emj.2009.087395enEmergency Medical ServicesHeart ArrestOut-of-Hospital Cardiac Arrest (OHCA)Brain InjuriesCardiac Arrest