• Login
    View Item 
    •   Home
    • North East Ambulance Service [NEAS]
    • Publications - North East Ambulance Service
    • View Item
    •   Home
    • North East Ambulance Service [NEAS]
    • Publications - North East Ambulance Service
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of amberCommunitiesPublication DateAuthorsTitlesSubjectsJournal TitleThis CollectionPublication DateAuthorsTitlesSubjectsJournal TitleProfilesView

    My Account

    LoginRegister

    About amber

    About amberGeneral Policies Terms of DepositSuggest an addition to amberamber Advisory NoteBrief Guide to searching amber

    Statistics

    Display statistics

    Paramedic initiated Lisinopril for acute stroke treatment (PIL-FAST): results from the pilot randomised controlled trial

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Average rating
     
       votes
    Cast your vote
    You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
    Star rating
     
    Your vote was cast
    Thank you for your feedback
    Author
    Shaw, Lisa
    Price, Christopher
    McLure, Sally
    Howel, Denise
    McColl, Elaine
    Younger, Paul cc
    Ford, Gary A.
    Keyword
    Emergency Medical Services
    Stroke
    Hypertension
    Antihypertensive Agents
    Survival Rate
    Journal title
    Emergency Medicine Journal
    
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/20.500.12417/406
    DOI
    10.1136/emermed-2013-202536
    Abstract
    Background High blood pressure (BP) during acute stroke is associated with poorer stroke outcome. Trials of treatments to lower BP have not resulted in improved outcome, but this may be because treatment commenced too late. Emergency medical service staff (paramedics) are uniquely placed to administer early treatment; however, experience of prehospital randomised controlled trials (RCTs) is very limited. Methods We conducted a pilot RCT to determine the feasibility of a definitive prehospital BP-lowering RCT in acute stroke. Paramedics were trained to identify, consent and deliver a first dose of lisinopril or placebo to adults with suspected stroke and hypertension while responding to the emergency call. Further treatment continued in hospital. Study eligibility, recruitment rate, completeness of receipt of study medication and clinical data (eg, BP) were collected to inform the design of a definitive RCT. Results In 14 months, 14 participants (median age=73 years, median National Institute of Health Stroke Scale=4) were recruited and received the prehospital dose of medication. Median time from stroke onset (as assessed by paramedic) to treatment was 70 min. Four participants completed 7 days of study treatment. Of ambulance transported suspected stroke patients, 1% were both study eligible and attended by a PIL-FAST paramedic. Conclusions It is possible to conduct a paramedic initiated double-blind RCT of a treatment for acute stroke. However, to perform a definitive RCT in a reasonable timescale, a large number of trained paramedics across several ambulance services would be needed to recruit the number of patients likely to be required. https://emj.bmj.com/content/emermed/31/12/994.full.pdf This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ http://dx.doi.org/10.1136/emermed-2013-202536
    ae974a485f413a2113503eed53cd6c53
    10.1136/emermed-2013-202536
    Scopus Count
    Collections
    Publications - North East Ambulance Service

    entitlement

     

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.