• Development and impact of a dedicated cardiac arrest response unit in a UK regional ambulance service

      Younger, Paul; McClelland, Graham; Fell, Paul (2015-05-19)
      Background Survival rates from out-of-hospital cardiac arrest (OHCA) vary, with figures from 2% to 12% reported nationally. Our ambulance service introduced a dedicated cardiac arrest response unit (CARU) as a trial in order to improve local patient outcomes by focussing training, extending the scope of practice and increasing exposure to cardiac arrests. CARU launched in January 2014 using a rapid response car staffed by senior paramedics responding to cardiac arrests within a 19 minute radius of their location⇓. VIEW INLINE VIEW POPUP Methods This work describes the development and impact of CARU during the initial six months (10/01/14 to 09/07/2014) of operations using prospectively collected data on all cases attended. Results CARU activated to 165 calls and attended 65% (n=107). 50% (n=54) of the cases attended were cardiac arrests where resuscitation was attempted. Return of Spontaneous Circulation (ROSC) was achieved during pre-hospital resuscitation in 52% (n=28) of cases. Patient outcomes are reported compared with service data for January to June 2014 inclusive and one year of historical data from the regional OHCA registry: Conclusions Based on these figures CARU appears to have a positive impact on ROSC and a significant impact on survival to discharge rates compared with the rest of the service (p<0.01, Fisher's exact test). Further work is needed to explore how CARU delivers this impact and how the CARU model can be implemented beyond the trial setting in a sustainable fashion. https://emj.bmj.com/content/32/6/503.2. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ DOI http://dx.doi.org/10.1136/emermed-2015-204979.2
    • Mechanical chest compression for out of hospital cardiac arrest: Systematic review and meta-analysis.

      Gates, Simon; Quinn, Tom; Deakin, Charles D.; Blair, Laura; Couper, Keith; Perkins, Gavin D. (2015-09)
    • Mechanical versus manual chest compression for out-of-hospital cardiac arrest (PARAMEDIC) : a pragmatic, cluster randomised controlled trial

      Perkins, Gavin D.; Lall, Ranjit; Quinn, Tom; Deakin, Charles D.; Cooke, Matthew W.; Horton, Jessica; Lamb, Sarah E.; Slowther, Anne-Marie; Woollard, Malcolm; Carson, Andy; et al. (2015-03)
    • Post-admission outcomes of participants in the PARAMEDIC trial: a cluster randomised trial of mechanical or manual chest compressions

      Ji, Chen; Lall, Ranjit; Quinn, Tom; Kaye, Charlotte; Haywood, K.; Horton, Jessica; Gordon, V.; Deakin, Charles D.; Pocock, Helen; Carson, Andrew; et al. (2017-09)
    • Prehospital adrenaline administration for out-of-hospital cardiac arrest: the picture in England and Wales

      Booth, Scott; Ji, Chen; Soar, Jasmeet; Siriwardena, Aloysius; Fothergill, Rachael; Spaight, Robert; Perkins, Gavin D. (2018-09)
    • Prehospital randomised assessment of a mechanical compression device in out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised trial and economic evaluation

      Gates, Simon; Lall, Ranjit; Quinn, Tom; Deakin, Charles D.; Cooke, Matthew W.; Horton, Jessica; Lamb, Sarah E.; Slowther, Anne-Marie; Woollard, Malcolm; Carson, Andrew; et al. (2017-04)
    • A randomized trial of epinephrine in out-of-hospital cardiac arrest

      Perkins, Gavin D.; Ji, Chen; Deakin, Charles D.; Quinn, Tom; Nolan, Jerry P.; Scomparin, Charlotte; Regan, Scott; Long, John; Slowther, Anne-Marie; Pocock, Helen; et al. (2018-08)
    • Regionalised cardiac arrest centres as a means to improve outcomes from out-of-hospital cardiac arrest in the UK: a literature review

      Miles, Steven (2016-12)
      Abstract published with permission. Introduction ‐ Sudden (out-of-hospital) cardiac arrest (OHCA) is recognised as a leading cause of death in the UK; however, survival rates remain significantly lower in the UK than in other developed countries such as Norway and Holland, which have specialised regional cardiac arrest systems and centres. Aims ‐ This review aims to look at the concept and potential benefits of specialised regional cardiac arrest centres, and to consider whether development of such centres, with bypass protocols to enable transportation of OHCA patients directly to these centres, could improve survival rates and patient outcomes in the UK. Methods ‐ Literature was identified through searching MEDLINE, ProQuest Central, CINAHL and PubMed Central databases, as well as relevant national websites, with the search terms ‘cardiac arrest’, ‘regionalised care’ and ‘out-of-hospital cardiac arrest’. Further screening used the inclusion criteria of publication within the previous 10 years (2006‐2016), English language and peer reviewed journals. Exclusion criteria included duplicated articles, articles with a primary focus on in-hospital arrests and focus on causes and prevention of cardiac arrest. Forty-three records resulted and their full texts were considered and reviewed individually to identify those supported by other sources and containing information to add to understanding of the topic Results ‐ A range of evidence is found to support the development of specialised regional cardiac arrest centres, with bypass protocols to enable ambulance staff to transport directly to these centres. Essential facilities for cardiac arrest centres are identified and potential barriers to development of these centres are discussed. Utilisation of paramedics with additional equipment and skills is considered to enable direct admissions to regional cardiac arrest centres to be effective. Conclusions ‐ Cardiac arrest centres, alongside bypass protocols to enable direct admission, could improve patient outcomes and survival rates for OHCA in the UK. For these measures to be effective some barriers to change need to be addressed and paramedics with additional skills and equipment used. Evidence from within the UK itself appears limited. Further research is needed within the UK, involving a multidisciplinary approach, with close working partnership between hospitals and the ambulance service in relation to development of regional cardiac arrest centres.
    • A service evaluation of a dedicated pre-hospital cardiac arrest response unit in the North East of England

      McClelland, Graham; Younger, Paul; Haworth, Daniel; Gospel, Amy; Aitken-Fell, Paul (2016-09)
      Abstract published with permission. Aim ‐ This article describes the introduction of a specialist cardiac arrest response unit by the North East Ambulance Service NHS Foundation Trust, with the aim of improving treatment and outcomes of out-of-hospital cardiac arrest patients, in the North East of England. Methods ‐ This study is a retrospective analysis of prospectively collected data, describing all cases where the cardiac arrest response unit was dispatched in the first 12 months of operation (January 2014 to January 2015). Results ‐ The cardiac arrest response unit was activated 333 times during the first year of operation and attended 164 out-of-hospital cardiac arrest patients. The cardiac arrest response unit demonstrated a significant impact on return of spontaneous circulation sustained to hospital (OR 1.74 (95% CI 1.19‐2.54), p = 0.004) and survival to discharge (OR 2.08 (95% CI 1.12‐3.84), p = 0.017) compared with the rest of the North East Ambulance Service NHS Foundation Trust. Conclusion ‐ The cardiac arrest response unit project demonstrated an improvement in return of spontaneous circulation and survival to discharge compared to current standard care. The specific mechanism, or mechanisms, by which the cardiac arrest response unit influences patient outcomes remain to be determined.