• Managing paediatric patients with pyrexia

      Wragg, Emily; Francis, Joseph; Amblum, Jeshni (2014-12)
    • Manual thrombectomy with platelet glycoprotein IIb/IIIa blockade is associated with lower mortality in patients treated with primary PCI (9266 patients from the London Heart Attack Group)

      Virdi, Gurkamal K.; Whitbread, Mark; Modi, B.N.; Jones, Daniel A.; Rathod, Krishnaraj S.; Lim, Pitt; Jain, A.J.; Akhtar, M.M.; Singh Kalra, S.; Crake, Tom; et al. (2013-05)
    • Manual thrombus aspiration is not associated with reduced mortality in patients treated with primary percutaneous coronary intervention: an observational study of 10,929 patients with St-segment elevation myocardial infarction from the London heart attack group.

      Jones, Daniel A.; Rathod, Krishnaraj S.; Gallagher, Sean; Jain, Ajay K.; Kalra, Sundeep Singh; Lim, Pitt; Crake, Tom; Ozkor, Mick; Rakhit, Roby; Knight, Charles J.; et al. (2015-04)
    • Mechanical thrombectomy use is associated with decreased mortality in patients treated with primary percutaneous coronary intervention (9935 patients from the London Heart Attack Group)

      Modi, B.N.; Jones, Daniel A.; Rathod, Krishnaraj S.; Akhtar, M.; Jain, Ajay K.; Singh Kalra, S.; Crake, Tom; Meier, Pascal; Astroulakis, Zoe; Dollery, C.; et al. (2013-05)
      Introduction During Primary Percutaneous Coronary Intervention (PPCI) post ST-Segment Myocardial Infarction (STEMI), distal embolisation of thrombus may lead to failure to re-establish normal flow in the infarct-related artery. Manual thrombus aspiration has been shown to improve coronary perfusion as assessed by time to ST-segment resolution and myocardial blush grade. Evidence supporting the benefit of thrombus aspiration on clinical outcomes, however, is limited and inconsistent. We aimed to assess the impact of manual thrombectomy on mortality in patients presenting with STEMI across all PPCI centres in London over a 5 year period from 2007 until 2012. Methods This was an observational cohort study of 9935 consecutive patients with STEMI treated with PPCI between 2007 and 2012 at eight tertiary cardiac centres across London, UK. Patient's details were recorded at the time of the procedure into the British Cardiac Intervention Society (BCIS) database. Outcome was assessed by all-cause mortality. Anonymous datasets from the eight centres were merged for analysis. The primary end-point was all-cause mortality at a median follow-up of 2.0 years (IQR range 1.1 –3.1 years). Results Of the 9935 consecutive STEMI patients presenting for PPCI, 2859 had mechanical thrombectomy. Patients who had manual thrombectomy were significantly younger (average age 60.6 vs 62.9) and were less likely to have had a previous myocardial infarction (11.9% of thrombectomy patients vs 14.7% of nonthrombectomy patients). Patients receiving manual thromectomy were found to be significantly more likely to have had PPCI via a radial approach (33.1% in thrombectomy patients vs 19.9% in nonthromectomy patients). Procedural success (defined as TIMI 3 flow at the end of procedure) was found to be significantly more likely in patients receiving manual thrombectomy (89.5% vs 86.7%) (table 1). Patients with thrombectomy use had similar unadjusted all-cause mortality rates to those without thrombectomy use (12.7% vs 16.5%, p=NS) during the 5-year follow-up period (figure 1). After multivariable adjustment thrombectomy use was associated with significantly decreased mortality rates (HR: 0.82, 95% CI 0.68 to 0.9, p=0.04). Conclusion Mechanical thrombectomy use appears to be associated with improved outcome, in the form of decreased mortality, in this large observational trial. https://heart.bmj.com/content/heartjnl/99/suppl_2/A32.2.full.pdf This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ http://dx.doi.org/10.1136/heartjnl-2013-304019.46
    • Mentorship within the paramedic profession: a practice educator's perspective

      Lane, Matthew; Rouse, James; Docking, Rachael E. (2016-05)
      Abstract published with permission. Background ‐ The rapid ascension of paramedic science within higher education is creating a significant culture change within the profession. Clinicians are now accountable for both their patients as well as the learning of their students. Mentoring practices in the paramedic profession have been adopted from the findings of professions allied to healthcare, including medicine, nursing and midwifery, where mentorship is well established. The insufficiencies of this model need to be tested to account for the idiosyncrasies of the paramedic role. Methods ‐ A convenience sample of paramedic educators were identified across two ambulance services. Focus groups were conducted to obtain rich data about participants’ opinions on current mentoring practices within the paramedic profession and recommendations for how this can be improved. Results ‐ Results demonstrated the importance of learning through observation, teaching skills and personal qualities in relation to the paramedic educator role, as previously identified in the literature produced by professions allied to healthcare. Paramedic educators also identified current challenges to practice that included organisational issues such as ‘support’, ‘recognition’ and the ‘mental well-being’ of students. Conclusions ‐ This is the first primary research to explore mentoring from the paramedic educator perspective. In order to undertake their role more effectively paramedic educators are looking for a greater investment into the culture of mentoring by ambulance services and universities to address the identified organisational issues.
    • Methodology and consent issues in emergency medicine: the ARREST trial in out-of-hospital cardiac arrest

      Perkins, Alexander; Patterson, Tiffany; Evans, Richard; Clayton, Tim; Fothergill, Rachael; Whitbread, Mark; Redwood, Simon R. (2019-10-22)
    • Mobile phones, in combination with a computer locator system, improve the response times of emergency medical services in central London

      Gossage, J.A.; Frith, D.P.; Carrell, T.W.G.; Damiani, Mike; Terris, J.; Burnand, K.G. (2008-03)
    • National initiatives to improve outcomes from out-of-hospital cardiac arrest in England

      Perkins, Gavin D.; Lockey, Andrew S.; de Belder, Mark A.; Moore, Fionna; Weissberg, Peter; Gray, Huon; Community Resuscitation Group (2016-07)
    • Older fallers: the risk and opportunity of ambulance non conveyance

      Halter, Mary; Snooks, Helen; Close, Jacqueline; Cheung, Wai Yee; Moore, Fionna (2006-04)
      Large numbers of older people fall every year. Interdisciplinary intervention can reduce the risk of falling, and the use of integrated falls services for ambulance attended patients has been promoted. Non conveyance of fallers by ambulance staff is high but the triage system is informal. This study tested whether the introduction of an assessment tool would enable emergency ambulance staff to leave older fallers at home safely. https://emj.bmj.com/content/23/4/e31 This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. http://creativecommons.org/licenses/by-nc/4.0/ http://dx.doi.org/10.1136/emj.2005.032946
    • Out-of-hospital cardiac arrest - optimal management

      Frohlich, Georg M.; Lyon, Richard; Sasson, Comilla; Crake, Tom; Whitbread, Mark; Indermuehle, Andreas; Timmis, Adam; Meier, Pascal (2013-11)
    • Out-of-Hospital Cardiac Arrest in London during the COVID-19 pandemic

      Fothergill, Rachael; Smith, Adam L.; Wrigley, Fenella; Perkins, Gavin (2021-03)
    • Out-of-hospital cardiac arrest in patients aged 35 years and under: a 4-year study of frequency and survival in London

      Donohoe, Rachael T.; Innes, Jennifer; Gadd, Stephen; Whitbread, Mark; Moore, Fionna (2010-01)
    • Out-of-hospital cardiac arrest in South Asian and white populations in London: database evaluation of characteristics and outcome

      Shah, Anoop S. V.; Bhopal, Raj S.; Gadd, Stephen; Donohoe, Rachel (2009-09-10)
      Objective: To compare out-of-hospital cardiac arrest (OOHCA) characteristics in white and South Asian populations within Greater London. Methods: Data for OOHCAs were extracted from 1 April 2003 to 31 March 2007. Primary study variables included age, gender, ethnicity, response times from 999 call to ambulance arrival, initial cardiac rhythm, whether bystander cardiopulmonary resuscitation was provided before arrival of the London Ambulance Service (LAS) NHS Trust crew, whether the arrest was witnessed (bystander or LAS crew) and hospital outcome, including survival to hospital admission and discharge. Results: Of 13 013 OOHCAs of presumed cardiac cause, 3161 (24.3%) had ethnicity codes assigned. These comprised 63.1% (n = 1995) white and 5.8% (n = 183) South Asian people, with the remainder from other backgrounds. White patients were on average 5 years older than South Asians (69.5 vs 64.6, p<0.005). Response time (7.48 min vs 7.46 min), bystander cardiopulmonary resuscitation (34.4% vs 29.7%), initial cardiac rhythm (29.5% vs 30.4%) and survival to admission (22.2% vs 22.5%) and discharge (8.7% vs 8.9%) were comparable between the two ethnic groups. South Asians were slightly more likely to have a witnessed an OOHCA than their white counterparts (OR = 1.1, 95% CI 1.0 to 1.2). Discussion: The quality of care provided was comparable between white and South Asian populations. The data support the emerging view that South Asians’ high mortality from coronary heart disease reflects higher incidence rather than higher case fatality. South Asians had an OOHCA at a significantly younger age. The study demonstrates the importance of ethnic coding within the emergency services. https://heart.bmj.com/content/96/1/27. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ DOI http://dx.doi.org/10.1136/hrt.2009.170183
    • Out-of-hours primary percutaneous coronary intervention for ST-elevation myocardial infarction is not associated with excess mortality: a study of 3347 patients treated in an integrated cardiac network

      Rathod, Krishnaraj S.; Jones, Daniel A.; Gallagher, Sean M.; Bromage, Daniel I.; Whitbread, Mark; Archbold, Andrew R.; Jain, Ajay K.; Mathur, Anthony; Wragg, Andrew; Knight, Charles J. (2013-06)
      OBJECTIVES: Timely delivery of primary percutaneous coronary intervention (PPCI) is the treatment of choice for ST-segment elevation myocardial infarction (STEMI). Optimum delivery of PPCI requires an integrated network of hospitals, following a multidisciplinary, consultant-led, protocol-driven approach. We investigated whether such a strategy was effective in providing equally effective in-hospital and long-term outcomes for STEMI patients treated by PPCI within normal working hours compared with those treated out-of-hours (OOHs). DESIGN: Observational study. SETTING: Large PPCI centre in London. PARTICIPANTS: 3347 STEMI patients were treated with PPCI between 2004 and 2012. The follow-up median was 3.3 years (IQR: 1.2-4.6 years). PRIMARY AND SECONDARY OUTCOME MEASURES: The primary endpoint was long-term major adverse cardiac events (MACE) with all-cause mortality a secondary endpoint. RESULTS: Of the 3347 STEMI patients, 1299 patients (38.8%) underwent PPCI during a weekday between 08:00 and 18:00 (routine-hours group) and 2048 (61.2%) underwent PPCI on a weekday between 18:00 and 08:00 or a weekend (OOHs group). There were no differences in baseline characteristics between the two groups with comparable door-to-balloon times (in-hours (IHs) 67.8 min vs OOHs 69.6 min, p=0.709), call-to-balloon times (IHs 116.63 vs OOHs 127.15 min, p=0.60) and procedural success. In hospital mortality rates were comparable between the two groups (IHs 3.6% vs OOHs 3.2%) with timing of presentation not predictive of outcome (HR 1.25 (95% CI 0.74 to 2.11). Over the follow-up period there were no significant differences in rates of mortality (IHs 7.4% vs OFHs 7.2%, p=0.442) or MACE (IHs 15.4% vs OFHs 14.1%, p=0.192) between the two groups. After adjustment for confounding variables using multivariate analysis, timing of presentation was not an independent predictor of mortality (HR 1.04 95% CI 0.78 to 1.39). CONCLUSIONS: This large registry study demonstrates that the delivery of PPCI with a multidisciplinary, consultant-led, protocol-driven approach provides safe and effective treatment for patients regardless of the time of presentation. https://bmjopen.bmj.com/content/bmjopen/3/6/e003063.full.pdf This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ http://dx.doi.org/10.1136/bmjopen-2013-003063
    • Outcome of 1051 octogenarians after primary percutaneous coronary intervention for ST elevation myocardial infarction: observational cohort from the London Heart Attack Group

      Bromage, D.I.; Jones, Daniel A.; Rathod, Krishnaraj S.; Lim, Pitt; Virdi, G.; Jain, A.J.; Singh Kalra, S.; Crake, Tom; Meier, Pascal; Astroulakis, Zoe; et al. (2013-05)
      Introduction The use of primary percutaneous coronary intervention (PCI) in octogenarians to treat ST elevation myocardial infarction (STEMI) is less than in other age groups. This is due in part to underrepresentation in clinical trials and perceived increased risk. We present long-term survival of a large cohort of elderly patients following primary PCI in London. Methods This was an observational study of 10 249 consecutive patients undergoing primary PCI for STEMI at eight London heart attack centres between January 2005 and November 2011. Patient’s details were recorded at the time of procedure into the British Cardiac Intervention Society (BCIS) database. Outcome was assessed by all-cause mortality. Anonymous datasets from the eight centres were merged for analysis. The primary end-point was all-cause mortality at a median follow-up of 3.0 years (IQR range 1.2–4.6 years). Results A total of 1051 octogenarians (10.3% of the study population) with an average age of 84.2 years (IQR 80–101) were treated with primary PCI during the study period. Over time, the annual proportion of octogenarians gradually increased from 9.1% in 2005 to 10.5% in 2010. Unsurprisingly, when compared to patients under 80, octogenarian STEMI patients included a higher proportion of women, and had a higher prevalence of hypertension, hypercholesterolaemia, multi-vessel disease, previous infarction and previous CABG (table 1). They additionally were less likely to undergo radial access, receive GPIIb/IIIa inhibitors or a drug-eluting stent. When compared with younger patients, primary PCI in octogenarians was less likely to achieve TIMI flow grade 3. However between 2005 and 2011 the rates of post-procedural TIMI flow grade 3 increased significantly from 80.5% in 2005 to 90% in 2011 (p for trend 0.05). The cumulative incidence of all-cause mortality during follow-up was significantly higher in the octogenarian group compared to the younger subgroup (51.6% vs 12.8%, p<0.0001) (figure 1). As expected, the hazard of death during follow-up increased with age (unadjusted HR 1.069 per year increase (95% CI 1.064 to 1.074), p<0.0001), which persisted after adjustment for other predictors of mortality (HR of 1.059 (95% CI 1.048 to 1.071), p<0.0001). Table 1 Under 80 Over 80 p Value Gender (female) 1800 (19.6%) 474 (45.4%) <0.0001 Hypertension 3692 (42.3%) 501 (51.3%) 0.02 Hypercholesterolaemia 3708 (42.5%) 548 (56.1%) <0.0001 Previous MI 1442 (16.9%) 182 (18.7%) 0.150 Previous CABG 264 (3.0%) 46 (4.6%) 0.010 Multi vessel disease 3821 (41.8%) 562 (54.0%) <0.0001 GPIIb/IIIa 6515 (74.4%) 530 (53.8%) <0.0001 DES use 4058 (45.9%) 311 (30.9%) <0.0001 Access (radial) 2115 (23.4%) 194 (18.8%) 0.001 Procedural success 6932 (88.3%) 736 (84.7%) 0.003 Figure 1 Heart May 2013 Vol 99 Suppl S2 A27 BCS Abstracts 2013 (NHS). Protected by copyright. on January 7, 2020 at Manchester University NHS Foundation Trust http://heart.bmj.com/ Heart: first published as 10.1136/heartjnl-2013-304019.37 on 24 May 2013. Downloaded from Conclusions Octogenarians constitute an important subgroup of STEMI patients. Data from London ’s experience would suggest that primary PCI rates are increasing in this group and that despite the high long term mortality, acute/year one rates survival rates are very encouraging. https://heart.bmj.com/content/heartjnl/99/suppl_2/A27.full.pdf This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ http://dx.doi.org/10.1136/heartjnl-2013-304019.37
    • Oxford Handbook of Pre-Hospital Care

      Fellows, Bob (2008-10)
      This is a small pocket guide written by a pair of eminent doctors with a clear market for other doctors who want to be more involved in the ‘sexy’ world of pre- and out-of-hospital care. Abstract published with permission.
    • Paramedic assessment of older adults after falls, including community care referral pathway: cluster randomized trial

      Snooks, Helen A.; Anthony, Rebecca; Chatters, Robin; Dale, Jeremy; Fothergill, Rachael T.; Gaze, Sarah; Halter, Mary; Humphreys, Ioan; Koniotou, Marina; Logan, Phillipa; et al. (2017-10)